Polymer Capsules for Plaque-Targeted In Vivo Delivery.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27358022.
- Also identified by DOI 10.1002/adma.201601754.
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Abstract
Targeted polymer capsules can selectively bind to unstable plaques in mice after intravenous injection. Different formulations of the capsules are explored with a synthetic/biopolymer hybrid capsule showing the best stability and small-molecule drug retention. The synthetic polymer is composed of pH-sensitive blocks (PDPA), low-binding blocks (PEG), and click-groups for postfunctionalization with targeting peptides specific to plaques.
Medical subject headings
- Capsules
- Drug Delivery Systems
- Plaque, Amyloid
- Polymers