Sorting Out Presenilins in Alzheimer's Disease.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 27368096.
- Also identified by DOI 10.1016/j.cell.2016.06.034.
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Abstract
Mutations in the presenilins that cause familial Alzheimer's disease alter the activity of these proteases to increase generation of an aggregation-prone isoform of the amyloid β-peptide (Aβ). How these mutations do so has been unclear. Sannerud et al. now show that regulation of subcellular localization plays a central role, advancing our understanding of the cell biology of Alzheimer's disease.
Medical subject headings
- Alzheimer Disease
- Presenilins