Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 27381735.
- Also identified by DOI 10.1038/ncomms12150 and PMC identifier 4935811.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions of MDSC to tumour progression through both immune-mediated mechanisms and those not directly associated with immune suppression. MDSC are the subject of intensive research with >500 papers published in 2015 alone. However, the phenotypic, morphological and functional heterogeneity of these cells generates confusion in investigation and analysis of their roles in inflammatory responses. The purpose of this communication is to suggest characterization standards in the burgeoning field of MDSC research.
Medical subject headings
- Cell Differentiation
- Myeloid-Derived Suppressor Cells
- Neoplasms
- Terminology as Topic