Hierarchical Fabrication of Engineered Vascularized Bone Biphasic Constructs via Dual 3D Bioprinting: Integrating Regional Bioactive Factors into Architectural Design.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27383032.
- Also identified by DOI 10.1002/adhm.201600505 and PMC identifier 5014673.
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Abstract
A biphasic artificial vascularized bone construct with regional bioactive factors is presented using dual 3D bioprinting platform technique, thereby forming a large functional bone grafts with organized vascular networks. Biocompatible mussel-inspired chemistry and "thiol-ene" click reaction are used to regionally immobilize bioactive factors during construct fabrication for modulating or improving cellular events.
Medical subject headings
- Bone and Bones
- Human Umbilical Vein Endothelial Cells
- Printing, Three-Dimensional
- Tissue Engineering