Self-Sealing Porous Silicon-Calcium Silicate Core-Shell Nanoparticles for Targeted siRNA Delivery to the Injured Brain.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27383373.
- Also identified by DOI 10.1002/adma.201600634 and PMC identifier 6274592.
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Abstract
Calcium ions react with silicic acid released from dissolving porous silicon nanoparticles to create an insoluble calcium silicate shell. The calcium silicate shell traps and protects an siRNA payload, which can be delivered to neuronal tissues in vitro or in vivo. Gene delivery is enhanced by the action of targeting and cell-penetrating peptides attached to the calcium silicate shell.
Medical subject headings
- Brain Injuries
- Calcium Compounds
- Nanoparticles
- RNA, Small Interfering
- Silicates
- Silicon