Porous Silicon and Polymer Nanocomposites for Delivery of Peptide Nucleic Acids as Anti-MicroRNA Therapies.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27383910.
- Also identified by DOI 10.1002/adma.201601646 and PMC identifier 5152671.
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Abstract
Self-assembled polymer/porous silicon nanocomposites overcome intracellular and systemic barriers for in vivo application of peptide nucleic acid (PNA) anti-microRNA therapeutics. Porous silicon (PSi) is leveraged as a biodegradable scaffold with high drug-cargo-loading capacity. Functionalization with a diblock polymer improves PSi nanoparticle colloidal stability, in vivo pharmacokinetics, and intracellular bioavailability through endosomal escape, enabling PNA to inhibit miR-122 in vivo.
Medical subject headings
- MicroRNAs
- Nanocomposites
- Peptide Nucleic Acids
- Polymers
- Silicon