Domestic dog exposure at birth reduces the incidence of atopic dermatitis.

Abstract

While the etiopathogenesis of atopic dermatitis is complex and poorly understood, neonatal exposures are important for disease occurrence. However, the effect of dog exposure on the risk of atopic dermatitis is unresolved. We investigated whether domestic dog exposure affected the risk of atopic dermatitis in children during the first 3 years of life. Copenhagen Prospective Studies on Asthma in Childhood (COPSAC) are ongoing prospective clinical birth cohort studies. Data from 411 children born to mothers with asthma (COPSAC₂₀₀₀ ) and 700 unselected children (COPSAC₂₀₁₀ ) were analyzed following the same protocols at the same research site. Atopic dermatitis was diagnosed prospectively according to the Hanifin-Rajka criteria. Parental history of asthma, eczema, or rhinitis was defined by self-reported physician diagnosis. In the COPSAC₂₀₀₀ , maternal specific serum IgE against eight inhalant allergens was sampled after the children's birth and at pregnancy week 24 in the COPSAC₂₀₁₀ cohort. Associations between dog exposure and atopic dermatitis were analyzed by Cox proportional hazard regression models and adjusted for lifestyle confounders. In the COPSAC₂₀₀₀ and COPSAC₂₀₁₀ cohorts, the risk of atopic dermatitis was significantly lower in children with domestic dog exposure (_adjusted HR = 0.46 [0.25-0.87], P = 0.02; and _adjusted HR = 0.58 [0.36-0.93], P = 0.03, respectively). The risk of atopic dermatitis decreased in a dose-dependent manner with increasing number of dogs (_adjusted HR = 0.58 [0.38-0.89], P = 0.01) in the COPSAC₂₀₁₀ . The protective effect was restricted to children born to mothers with atopic disease in the unselected COPSAC₂₀₁₀ cohort (_adjusted HR = 0.39 [0.19-0.82], P = 0.01), as no effect was observed in children born to mothers without atopic disease (_adjusted HR = 0.92 [0.49-1.73], P = 0.79). Paternal atopic status did not affect the risk of atopic dermatitis. We found no significant interaction between the CD14 T/T genotype and domestic dog exposure in either cohort (COPSAC₂₀₀₀ , P = 0.36; and COPSAC₂₀₁₀ cohort, P = 0.42). Neonatal domestic dog exposure was associated with a strongly reduced risk of atopic dermatitis in two independent birth cohorts and in a dose-dependent manner. While the mechanisms involved are unclear, our findings raise the question of whether in utero exposures may affect the risk of atopic dermatitis and emphasize the importance of the early environment for disease trajectory.