Burning Fat Fuels Leukemic Stem Cell Heterogeneity.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 27392217.
- Also identified by DOI 10.1016/j.stem.2016.06.014.
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Abstract
Obese leukemia patients exhibit reduced survival after chemotherapy, suggesting an important role of adipose tissue in disease progression. In this issue of Cell Stem Cell, Ye et al. (2016) reveal metabolic heterogeneity in leukemic stem cell (LSC) subpopulations and show that chemotherapy-resistant CD36+ LSCs co-opt gonadal adipose tissue to support their metabolism and survival.
Medical subject headings
- Adipose Tissue
- Leukemia, Myeloid, Acute
- Neoplastic Stem Cells
- Obesity