Metabolic RemodeLIN of Pluripotency.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 27392218.
- Also identified by DOI 10.1016/j.stem.2016.06.016.
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Abstract
Cellular metabolism is a key regulator of cell fate, including fate in pluripotent stem cells. Now in Cell Stem Cell, Zhang et al. (2016) show that Lin28 controls the metabolic transition from naive to primed pluripotency by directly repressing oxidative metabolism genes and metabolic intermediates involved in epigenetic regulation independently of let-7.
Medical subject headings
- Epigenesis, Genetic
- Pluripotent Stem Cells