Gut microbiome analysis in neuromyelitis optica reveals overabundance of Clostridium perfringens.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 27398819.
- Also identified by DOI 10.1002/ana.24718 and PMC identifier 5053302.
- Licence recorded as CC BY-NC-ND.
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Abstract
T cells from neuromyelitis optica (NMO) patients, which recognize the immunodominant epitope of aquaporin-4, exhibit Th17 polarization and cross-react with a homologous sequence of a Clostridium perfringens adenosine triphosphate-binding cassette transporter. Therefore, this commensal microbe might participate in NMO pathogenesis. We examined the gut microbiome by PhyloChip G3 from 16 NMO patients, 16 healthy controls (HC), and 16 multiple sclerosis patients. A significant difference in the abundance of several microbial communities was observed between NMO and HC (Adonis test, p = 0.001). Strikingly, C. perfringens was overrepresented in NMO (p = 5.24 × 10(-8) ). These observations support a potential role for C. perfringens in NMO pathogenesis. Ann Neurol 2016;80:443-447.
Medical subject headings
- Clostridium perfringens
- Gastrointestinal Microbiome
- Multiple Sclerosis
- Neuromyelitis Optica