AplusB: A Web Application for Investigating A + B Designs for Phase I Cancer Clinical Trials.
Where this comes from
- Record sourced from PubMed, PMID 27403961.
- Also identified by DOI 10.1371/journal.pone.0159026 and PMC identifier 4942070.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
In phase I cancer clinical trials, the maximum tolerated dose of a new drug is often found by a dose-escalation method known as the A + B design. We have developed an interactive web application, AplusB, which computes and returns exact operating characteristics of A + B trial designs. The application has a graphical user interface (GUI), requires no programming knowledge and is free to access and use on any device that can open an internet browser. A customised report is available for download for each design that contains tabulated operating characteristics and informative plots, which can then be compared with other dose-escalation methods. We present a step-by-step guide on how to use this application and provide several illustrative examples of its capabilities.
Medical subject headings
- Clinical Trials, Phase I as Topic
- Internet
- Neoplasms
- Programming Languages
- Research Design