Expanding Our Understanding of mtDNA Deletions.
Level V
Where this comes from
- Record sourced from PubMed, PMID 27411002.
- Also identified by DOI 10.1016/j.cmet.2016.06.024.
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Abstract
Clonal expansion of mtDNA deletions compromises mitochondrial function in human disease and aging, but how deleterious mtDNA genomes propagate has remained unclear. In this issue (Gitschlag et al., 2016) and in a recent Nature publication, C. elegans studies implicate the mitochondrial unfolded protein response (UPR(mt)) and offer mechanistic insights into this process.
Medical subject headings
- Caenorhabditis elegans
- DNA, Mitochondrial