Elevated GDF11 Is a Risk Factor for Age-Related Frailty and Disease in Humans.
Level V
Where this comes from
- Record sourced from PubMed, PMID 27411004.
- Also identified by DOI 10.1016/j.cmet.2016.06.017.
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Abstract
GDF11 was reported to decline with age and to have muscle and heart rejuvenating effects. These reports were disputed. A Cell Metabolism paper now shows that in human beings, GDF11 does not decline with age and is actually a risk factor for frailty and other morbidities (Schafer et al., 2016).
Medical subject headings
- Bone Morphogenetic Proteins
- Growth Differentiation Factors