Renal Clearable Organic Nanocarriers for Bioimaging and Drug Delivery.

Kang, Homan; Gravier, Julien; Bao, Kai; Wada, Hideyuki; Lee, Jeong Heon; Baek, Yoonji; El Fakhri, Georges; Gioux, Sylvain et al. · Adv Mater · 2016

basic_science · Level V

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Abstract

Renally cleared zwitterionic nanocarriers (H-Dots) are composed of ε-polylysine backbone for charge variations, near-infrared fluorophores for bioimaging, and β-cyclodextrins for potential drug delivery. H-Dots show ideal systemic circulation and rapid distribution and excrete from normal tissue/organ via renal excretion after complete targeting to the tumor site without nonspecific uptake by the immune system.

Medical subject headings