Opening a Chromatin Gate to Metastasis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27419866.
- Also identified by DOI 10.1016/j.cell.2016.06.031 and PMC identifier 5546407.
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Abstract
What changes need to occur in a primary tumor to make it metastatic? Denny et al. address this question for small cell lung cancer (SCLC), finding that changes in genomic accessibility mediated by a single transcription factor, NFIB, comprise at least one mechanism influencing metastasis.
Medical subject headings
- Cell Line, Tumor
- Chromatin