Diagnostic potential of tumor DNA from ovarian cyst fluid.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 27421040.
- Also identified by DOI 10.7554/eLife.15175 and PMC identifier 4946896.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
We determined whether the mutations found in ovarian cancers could be identified in the patients' ovarian cyst fluids. Tumor-specific mutations were detectable in the cyst fluids of 19 of 23 (83%) borderline tumors, 10 of 13 (77%) type I cancers, and 18 of 18 (100%) type II cancers. In contrast, no mutations were found in the cyst fluids of 18 patients with benign tumors or non-neoplastic cysts. Though large, prospective studies are needed to demonstrate the safety and clinical utility of this approach, our results suggest that the genetic evaluation of cyst fluids might be able to inform the management of the large number of women with these lesions.
Medical subject headings
- Cyst Fluid
- DNA
- Mutation
- Ovarian Cysts
- Ovarian Neoplasms