Deep brain stimulation and climbing fiber synaptic pathology in essential tremor.
Where this comes from
- Record sourced from PubMed, PMID 27422481.
- Also identified by DOI 10.1002/ana.24728 and PMC identifier 5016237.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Essential tremor (ET) patients have abnormal climbing fiber (CF) synapses in the parallel fiber territory in the cerebellum, and these abnormal CF synapses are inversely correlated with tremor severity. We therefore examined CF synaptic pathology in ET cases with and without thalamic deep brain stimulation (DBS) and assessed the association with tremor severity. We found that CF synaptic pathology was inversely correlated with tremor severity in ET cases without DBS, and this correlation disappeared in ET cases with DBS. Our data suggest that DBS might have effects in modulating excitatory synapses in ET cerebellum, in addition to its symptomatic effects on tremor. Ann Neurol 2016;80:461-465.
Medical subject headings
- Cerebellar Diseases
- Deep Brain Stimulation
- Essential Tremor
- Nerve Fibers
- Synapses