Accumulation of MxB/Mx2-resistant HIV-1 Capsid Variants During Expansion of the HIV-1 Epidemic in Human Populations.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27428433.
- Also identified by DOI 10.1016/j.ebiom.2016.04.020 and PMC identifier 4919602.
- Licence recorded as CC BY-NC-ND.
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Abstract
Recent studies have identified human myxovirus resistance protein 2 (MxB or Mx2) as an interferon induced inhibitor of HIV-1 replication. However, whether HIV-1 can overcome MxB restriction without compromise of viral fitness has been undefined. Here, we have discovered that naturally occurring capsid (CA) variants can render HIV-1 resistant to the activity of MxB without losing viral infectivity or the ability to escape from interferon induction. Moreover, these MxB resistant HIV-1 variants do not lose MxB recognition. Surprisingly, MxB resistant CA variants are most commonly found in the Clade C HIV-1 that is the most rapidly expanding Clade throughout the world. Accumulation of MxB resistant mutations is also observed during HIV-1 spreading in human populations. These findings support a potential role for MxB as a selective force during HIV-1 transmission and evolution.
Medical subject headings
- Anti-HIV Agents
- Capsid Proteins
- Drug Resistance, Viral
- HIV Infections
- HIV-1
- Myxovirus Resistance Proteins