Prediction of presence of kidney disease in patients undergoing intravenous iodinated contrast enhanced computed tomography: a validation study.

Abstract

To validate two previously presented models containing risk factors to identify patients with estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m² or eGFR <45 ml/min/1.73 m². In random patients undergoing intravenous contrast-enhanced computed tomography (CECT) the following risk factors were assessed: history of urological/nephrological disease, hypertension, diabetes mellitus, anaemia, congestive heart failure, other cardiovascular disease or multiple myeloma or Waldenström disease. Data on kidney function, age, gender and type and indication of CECT were also registered. We studied two models: model A-diabetes mellitus, history of urological/nephrological disease, cardiovascular disease, hypertension; model B-diabetes mellitus, history of urological/nephrological disease, age >75 years and congestive heart failure. For each model, associations with eGFR <60 ml/min/1.73 m² or eGFR <45 ml/min/1.73 m² was studied. A total of 1,001 patients, mean age 60.36 years were included. In total, 92 (9.2 %) patients had an eGFR <60 ml/min/1.73 m² and 11 (1.1 %) patients an eGFR <45 ml/min/1.73 m². Model A detected 543 patients: 81 with eGFR <60 ml/min/1.73 m² (missing 11) and all 11 with eGFR <45 ml/min/1.73 m². Model B detected 420 patients: 70 (missing 22) with eGFR <60 ml/min/1.73 m² and all 11 with eGFR <45 ml/min/1.73 m². Associations were significant (p < 0.05). Model B resulted in the lowest superfluous eGFR measurements while detecting all patients with eGFR <45 ml/min/1.73 m² and nearly all with eGFR <60 ml/min/1.73 m². • Less than 10% of patients undergoing contrast-enhanced CT have an eGFR of <60ml/min/1.73m ² • Four risk factors can be used to detect pre-existent kidney disease • It is safe to reduce eGFR measurements using a four-risk-factor model.