Krüppel-Like Factor 12 Promotes Colorectal Cancer Growth through Early Growth Response Protein 1.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27442508.
- Also identified by DOI 10.1371/journal.pone.0159899 and PMC identifier 4956169.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Krüppel-like factor 12 (KLF12) is a transcription factor that plays a role in normal kidney development and repression of decidualization. KLF12 is frequently elevated in esophageal adenocarcinoma and has been reported to promote gastric cancer progression. Here, we examined the role of KLF12 in colorectal cancer (CRC). Indeed, KLF12 promotes tumor growth by directly activating early growth response protein 1 (EGR1). The levels of KLF12 and EGR1 correlate synergistically with a poor prognosis. These results indicate that KLF12 likely plays an important role in CRC and could serve as a potential prognostic marker and therapeutic target.
Medical subject headings
- Colorectal Neoplasms
- Early Growth Response Protein 1
- Gene Expression Regulation, Neoplastic
- Kruppel-Like Transcription Factors