Concurrence of chromosome 6 chromothripsis and glioblastoma metastasis.
case_report · Level V
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- Record sourced from PubMed, PMID 27447440.
- Also identified by DOI 10.3171/2016.4.JNS153052.
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Abstract
The authors report an unusual case of a widely metastatic glioblastoma. DNA copy number microarray profile of the resected specimen revealed complex rearrangements found throughout chromosome 6, a phenomenon known as chromothripsis. Such chromothripsis pattern was not observed in 50 nonmetastatic glioblastoma specimens analyzed. Analysis of the 1000+ gliomas profiled by The Cancer Genome Atlas (TCGA) data set revealed one case of chromosome 6 chromothripsis resembling the case described here. This TCGA patient died within 6 months of undergoing tumor resection. Implications of these findings are reviewed in the context of the current literature.
Medical subject headings
- Brain Neoplasms
- Chromosomes, Human, Pair 6
- Chromothripsis
- Glioblastoma