Genomic correction of familial cardiomyopathy in human engineered cardiac tissues.
basic_science · Level V
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- Record sourced from PubMed, PMID 27450564.
- Also identified by PMC identifier 6425468.
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Abstract
In this study, we used three-dimensional human engineered cardiac tissue technology to directly show that phospholamban (PLN) R14del mutation impairs cardiac contractility and to demonstrate restoration of contractile properties with targeted genetic correction of this inheritable form of dilated cardiomyopathy.
Medical subject headings
- Cardiomyopathies