Simultaneously Photo-Cleavable and Activatable Prodrug-Backboned Block Copolymer Micelles for Precise Anticancer Drug Delivery.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27460551.
- Also identified by DOI 10.1002/adhm.201600470.
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Abstract
A simultaneously photo-cleavable and activatable prodrug-backboned block copolymer (BCP) micelle strategy is demonstrated. Without light treatment, the micelles stay silent and inactivated, being biocompatible to normal tissues. Concurrent chain cleavage of BCP micelles and the activation of Pt(IV) prodrug could be temporally and spatially triggered by UV or even visible light for precise anticancer drug delivery.
Medical subject headings
- Antineoplastic Agents
- Polymers
- Prodrugs