Association Between Kidney Cancer and Occupational Exposure to Trichloroethylene.
retrospective_cohort · Level III
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- Record sourced from PubMed, PMID 27465103.
- Also identified by DOI 10.1097/JOM.0000000000000838.
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Abstract
This study investigates the association between occupational exposure to trichloroethylene (TCE) and kidney cancer, as this correlation has been questioned. The incidence of cancers was studied in a dynamic cohort of 997 male workers who for many years had been occupationally exposed to TCE. During a 50-year observation period, 13 cases of kidney cancer were observed (7.5 expected) with a standardized incidence ratio of 1.7 and a 95% confidence interval of 1.0 to 3.0. Four other cases, not included in the SIR analysis, were also observed. Long-term TCE exposure was positively confirmed for 14 of the 17 incident cases. There is reason to assume that the remaining cases also had been exposed to TCE. The present study supports the view that TCE is a kidney carcinogen.
Medical subject headings
- Kidney Neoplasms
- Occupational Exposure
- Trichloroethylene