In Praise of Descriptive Science: A Breath of Fresh AIRE.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27471960.
- Also identified by DOI 10.1016/j.cell.2016.07.018 and PMC identifier 5294994.
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Abstract
Meyer et al. find that subjects lacking the AIRE gene, critical for self-tolerance in T lymphocytes, show a broad range of autoantibody specificities, which can have extremely high affinities. The data also suggest that some of these autoantibodies can, surprisingly, prevent some types of autoimmunity, particularly type I diabetes.
Medical subject headings
- Autoimmunity
- Self Tolerance