Injectable and Cytocompatible Tough Double-Network Hydrogels through Tandem Supramolecular and Covalent Crosslinking.
basic_science · Level V
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- Record sourced from PubMed, PMID 27479881.
- Also identified by DOI 10.1002/adma.201602268 and PMC identifier 7437955.
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Abstract
Double-network theory is extended to include guest-host interactions, enabling injectability and cytcompatibility of tough hydrogels. Noncovalent interactions are used as a sacrificial network to toughen covalently crosslinked hydrogels formed from hyaluronic acid. Shear thinning of supramolecular bonds allows hydrogel injection and rapid self-healing, while gentle reaction conditions permit cell encapsulation with high viability.