Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27481093.
- Also identified by DOI 10.1038/ncomms12207 and PMC identifier 4974641.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The molecular mechanisms that regulate B-cell development and tolerance remain incompletely understood. In this study, we identify a critical role for the miR-17∼92 microRNA cluster in regulating B-cell central tolerance and demonstrate that these miRNAs control early B-cell development in a cell-intrinsic manner. While the cluster member miR-19 suppresses the expression of Pten and plays a key role in regulating B-cell tolerance, miR-17 controls early B-cell development through other molecular pathways. These findings demonstrate differential control of two closely linked B-cell developmental stages by different members of a single microRNA cluster through distinct molecular pathways.
Medical subject headings
- B-Lymphocytes
- Immune Tolerance
- Lymphocyte Activation
- MicroRNAs
- PTEN Phosphohydrolase