Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27492130.
- Also identified by DOI 10.1038/ncomms12152 and PMC identifier 4980448.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Cold- and β3-adrenoceptor agonist-induced sympathetic activation leads to angiogenesis and UCP1-dependent thermogenesis in mouse brown and white adipose tissues. Here we show that endothelial production of PDGF-CC during white adipose tissue (WAT) angiogenesis regulates WAT browning. We find that genetic deletion of endothelial VEGFR2, knockout of the Pdgf-c gene or pharmacological blockade of PDGFR-α impair the WAT-beige transition. We further show that PDGF-CC stimulation upregulates UCP1 expression and acquisition of a beige phenotype in differentiated mouse WAT-PDGFR-α(+) progenitor cells, as well as in human WAT-PDGFR-α(+) adipocytes, supporting the physiological relevance of our findings. Our data reveal a paracrine mechanism by which angiogenic endothelial cells modulate adipocyte metabolism, which may provide new targets for the treatment of obesity and related metabolic diseases.
Medical subject headings
- Adipose Tissue, Beige
- Endothelial Cells
- Lymphokines
- Neovascularization, Physiologic
- Platelet-Derived Growth Factor
- Thermogenesis