Stressed-Out HSCs Turn Up p38α and Purine to Proliferate.
editorial · Level V
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- Record sourced from PubMed, PMID 27494667.
- Also identified by DOI 10.1016/j.stem.2016.07.013.
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Abstract
Changes in cellular metabolism drive hematopoietic stem cell (HSC) behavior during homeostasis, although whether they control HSC behavior during stress conditions is unclear. In this issue of Cell Stem Cell, Karigane et al. (2016) identify a p38α-dependent pathway that alters purine metabolism in HSCs during stress hematopoiesis, promoting hematopoietic recovery.
Medical subject headings
- Hematopoiesis
- Hematopoietic Stem Cells