Recent developments in the detection and management of acute kidney injury.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 27496911.
- Also identified by DOI 10.1136/archdischild-2015-309381 and PMC identifier 5256404.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Acute kidney injury (AKI) is a common condition in children admitted to hospital and existing serum and urine biomarkers are insensitive. There have been significant developments in stratifying the risk of AKI in children and also in the identification of new AKI biomarkers. Risk stratification coupled with a panel of AKI biomarkers will improve future detection of AKI, however, paediatric validation studies in mixed patient cohorts are required. The principles of effective management rely on treating the underlying cause and preventing secondary AKI by the appropriate use of fluids and medication. Further therapeutic innovation will depend on improving our understanding of the basic mechanisms underlying AKI in children.
Medical subject headings
- Acute Kidney Injury
- Biomarkers