Metabolic Pathways and Networks Associated With Tobacco Use in Military Personnel.
Where this comes from
- Record sourced from PubMed, PMID 27501098.
- Also identified by DOI 10.1097/JOM.0000000000000763 and PMC identifier 4978145.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The aim of this study is to use high-resolution metabolomics (HRM) to identify metabolic pathways and networks associated with tobacco use in military personnel. Four hundred deidentified samples obtained from the Department of Defense Serum Repository were classified as tobacco users or nonusers according to cotinine content. HRM and bioinformatic methods were used to determine pathways and networks associated with classification. Eighty individuals were classified as tobacco users compared with 320 nonusers on the basis of cotinine levels at least 10 ng/mL. Alterations in lipid and xenobiotic metabolism, and diverse effects on amino acid, sialic acid, and purine and pyrimidine metabolism were observed. Importantly, network analysis showed broad effects on metabolic associations not simply linked to well-defined pathways. Tobacco use has complex metabolic effects that must be considered in evaluation of deployment-associated environmental exposures in military personnel.
Medical subject headings
- Cotinine
- Metabolic Networks and Pathways
- Military Personnel
- Tobacco Use