Long-term preclinical magnetic resonance imaging alterations in sporadic Creutzfeldt-Jakob disease.
case_report · Level V
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- Record sourced from PubMed, PMID 27501375.
- Also identified by DOI 10.1002/ana.24757.
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Abstract
An asymptomatic 74-year-old woman, on follow-up for a carotid body tumor, showed magnetic resonance imaging (MRI) focal restricted diffusion confined to the left temporal and occipital cortices. Thirteen months later, diffusion-weighted images revealed a bilateral cortical ribbon sign involving all lobes. After 1 month, the patient developed gait instability and cognitive decline rapidly evolving to severe dementia and death within 3 months. Prion protein gene sequence, molecular, and neuropathological studies confirmed the diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD) MM1 subtype. Here we show the kinetics of MRI changes and prion spreading in preclinical sCJD MM1. Ann Neurol 2016;80:629-632.
Medical subject headings
- Cerebral Cortex
- Creutzfeldt-Jakob Syndrome
- Disease Progression