Colonic Macrophages "Remote Control" Adipose Tissue Inflammation and Insulin Resistance.

Biswas, Subhra K; Bonecchi, Raffaella · Cell Metab · 2016

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Abstract

The early events linking diet-induced adipose tissue inflammation and insulin resistance remain poorly understood. In this issue of Cell Metabolism, Kawano et al. (2016) show that infiltration of colonic pro-inflammatory macrophages orchestrated by the intestinal CCL2/CCR2 axis kick-starts this process during high-fat-diet feeding.

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