When Hexokinase Gets that NAG-ing Feeling….
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 27508867.
- Also identified by DOI 10.1016/j.cmet.2016.07.021 and PMC identifier 5572107.
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Abstract
Immune cell recognition of bacterial products usually occurs via specific pattern recognition receptors, but new research recently published in Cell by Wolf et al. (2016) demonstrates that the glycolytic enzyme hexokinase can act as an innate immune sensor by binding to bacterial derived N-acetylglucosamine (NAG).
Medical subject headings
- Acetylglucosamine
- Hexokinase