Two Cases of Hepatosplenic T-Cell Lymphoma in Adolescents Treated for Autoimmune Hepatitis.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 27516526.
- Also identified by DOI 10.1542/peds.2015-4245.
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Abstract
We report the first 2 cases of hepatosplenic T-cell lymphoma in adolescents diagnosed with autoimmune hepatitis under long-term treatment with azathioprine. Patients presented with fatigue, hepatosplenomegaly, and pancytopenia. The diagnosis could be confirmed performing biopsies of liver and spleen or bone marrow, which demonstrated infiltration of neoplastic T lymphocytes with the typical phenotype with both markers, CD56(+) and TCRγδ(+) Thus, these cases emphasize the need to constantly reevaluate the administered dose and duration of thiopurines for autoimmune hepatitis, especially in adolescents.
Medical subject headings
- Azathioprine
- Hepatitis, Autoimmune
- Immunosuppressive Agents
- Liver Neoplasms
- Lymphoma, T-Cell
- Splenic Neoplasms