Look Out Autophagy, Ubiquilin UPS Its Game.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27518558.
- Also identified by DOI 10.1016/j.cell.2016.07.048.
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Abstract
Mutations in Ubiquilin-2 are linked to the onset of amyotrophic lateral sclerosis, but its connection to disease processes has remained unknown. Hjerpe et. al now report that Ubiquilin-2 enables the ubiquitin proteasome system (UPS) to single-handedly clear aggregated proteins, a cellular function previously thought to rely at least partially on autophagy.
Medical subject headings
- Proteasome Endopeptidase Complex
- Ubiquitin