Inhibition of NLRP3 inflammasome as a therapeutic intervention in crystal-induced nephropathy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27521105.
- Also identified by DOI 10.1016/j.kint.2016.05.003.
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Abstract
Inflammasomes are important components of innate immunity system. Dysregulation of inflammasomes activation is central to the pathogenesis of inflammatory diseases. The measurement of inflammasomes activity especially in in vivo settings should give us important information to regulate inflammatory events. Ludwig-Portugall et al. clearly visualized the intrarenal activation of inflammasome in a murine model of crystal nephropathy using a proteolytic luciferase-based reporter, and showed that the blockade of NLRP3 inflammasome may prevent renal injuries.
Medical subject headings
- Inflammasomes
- Interleukin-1beta