β3-Adrenoreceptors in the thick ascending limb of Henle and in principal cells of the collecting duct work to concentrate urine.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27521107.
- Also identified by DOI 10.1016/j.kint.2016.04.013.
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Abstract
β3-Adrenoreceptors and their importance to increase sodium reabsorption in the thick ascending loop of Henle and to increase water reabsorption in principal cells of the collecting duct are, for the first time, described here. This is an integrated brain response to dehydration perceived by osmosensitive cells in the hypothalamus and triggering through vasopressin axonal and dendritic release a coordinated response implicating vasopressin V2 receptors and β3-adrenoreceptors on the luminal membrane of cortical collecting duct cells.
Medical subject headings
- Kidney Tubules
- Receptors, Adrenergic, beta-3