The rise of FGF23: should insights from population-based studies inform future clinical trials?
Where this comes from
- Record sourced from PubMed, PMID 27521109.
- Also identified by DOI 10.1016/j.kint.2016.06.005.
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Abstract
Research on the potential effects of fibroblast growth factor 23 (FGD23) in chronic kidney disease (CKD) has been galvanized by work suggesting that the FGF23 level rises even before the parathyroid hormone (PTH) level. However, new work suggests that the levels of both FGF23 and PTH may begin to rise much earlier than previously appreciated, indeed well before the establishment of clinically evident CKD. These findings challenge previous understanding and could affect the design of interventional trials designed to lower FGF23 levels.
Medical subject headings
- Fibroblast Growth Factors
- Parathyroid Hormone