Simultaneous Near-Infrared and Two-Photon In Vivo Imaging of H<sub>2</sub> O<sub>2</sub> Using a Ratiometric Fluorescent Probe based on the Unique Oxidative Rearrangement of Oxonium.
basic_science · Level V
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- Record sourced from PubMed, PMID 27545434.
- Also identified by DOI 10.1002/adma.201602939.
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Abstract
A new ratiometric fluorescent H<sub>2</sub> O<sub>2</sub> probe, benzopyrylium-coumarin (BC), is designed by using an oxonium moiety as the unique H<sub>2</sub> O<sub>2</sub> response site. The BC probe exhibits an extremely large emission shift of 221 nm in response to H<sub>2</sub> O<sub>2</sub> , and is successfully applied for the simultaneous near-infrared and two-photon imaging of H<sub>2</sub> O<sub>2</sub> in living cells, mouse-liver tissues, and zebrafish.
Medical subject headings
- Photons