Effects of Sodium Restriction on Activation of the Renin-Angiotensin-Aldosterone System and Immune Indices During HIV Infection.
prospective_cohort · Level II
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- Record sourced from PubMed, PMID 27549584.
- Also identified by PMC identifier 5079375.
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Abstract
Human immunodeficiency virus (HIV)-infected patients demonstrate increased activation of the renin-angiotensin-aldosterone system (RAAS). We evaluated changes in immune markers with physiological RAAS activation. Immune activation markers were assessed serially in 18 HIV-infected and 7 non-HIV-infected subjects consuming an ad libitum diet followed by a standardized low-sodium diet. Levels of CCL-2 (P = .0004) and soluble CD163 (P = .0001) significantly increased with sodium restriction and RAAS activation, compared with levels in individuals with ad libitum sodium intake, among chronically treated HIV-infected subjects (mean duration of ART [±SEM], 11 ± 1 years), but not among non-HIV-infected subjects of similar age and sex. Dietary sodium restriction, which activates RAAS, uniquely stimulates critical indices of immune activation during HIV infection. NCT01407237.
Medical subject headings
- HIV Infections
- Renin-Angiotensin System
- Sodium