The metabolic fate of acetate in cancer.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 27562461.
- Also identified by DOI 10.1038/nrc.2016.87 and PMC identifier 8992383.
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Abstract
Recent high-profile reports have reignited an interest in acetate metabolism in cancer. Acetyl-CoA synthetases that catalyse the conversion of acetate to acetyl-CoA have now been implicated in the growth of hepatocellular carcinoma, glioblastoma, breast cancer and prostate cancer. In this Review, we discuss how acetate functions as a nutritional source for tumours and as a regulator of cancer cell stress, and how preventing its (re)capture by cancer cells may provide an opportunity for therapeutic intervention.
Medical subject headings
- Acetates
- Acetyl Coenzyme A
- Neoplasms