The interplay between cell signalling and the mevalonate pathway in cancer.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 27562463.
- Also identified by DOI 10.1038/nrc.2016.76.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The mevalonate (MVA) pathway is an essential metabolic pathway that uses acetyl-CoA to produce sterols and isoprenoids that are integral to tumour growth and progression. In recent years, many oncogenic signalling pathways have been shown to increase the activity and/or the expression of MVA pathway enzymes. This Review summarizes recent advances and discusses unique opportunities for immediately targeting this metabolic vulnerability in cancer with agents that have been approved for other therapeutic uses, such as the statin family of drugs, to improve outcomes for cancer patients.
Medical subject headings
- Metabolic Networks and Pathways
- Mevalonic Acid
- Neoplasms
- Signal Transduction