Tag Team Ubiquitin Ligases.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27565338.
- Also identified by DOI 10.1016/j.cell.2016.08.014.
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Abstract
Cullin-RING (CRL) and RING1-IBR-RING2 (RBR) are two distinct types of ubiquitin ligases. In this issue, Scott et al. show that CRLs activate the RBR enzyme ARIH1 to initiate ubiquitin chains on CRL substrates, thereby marking an unexpected and important advance in our understanding of both enzymes.
Medical subject headings
- Ubiquitin
- Ubiquitin-Protein Ligases