Getting IN on Viral RNA Condensation and Virion Maturation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27565339.
- Also identified by DOI 10.1016/j.cell.2016.08.013 and PMC identifier 6941196.
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Abstract
The retroviral enzyme integrase plays an essential role in the virus replication cycle by catalyzing the covalent insertion of newly synthesized viral DNA into the host cell chromosome early after infection. Now, Kessl et al. report a second function of integrase: binding to the viral RNA genome in virion particles late in the virus replication cycle to promote particle maturation.
Medical subject headings
- HIV-1
- RNA, Viral