Identification of Loci at 1q21 and 16q23 That Affect Susceptibility to Inflammatory Bowel Disease in Koreans.
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Where this comes from
- Record sourced from PubMed, PMID 27569725.
- Also identified by DOI 10.1053/j.gastro.2016.08.025.
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Abstract
Recent genome-wide association studies have identified more than 200 regions that affect susceptibility to inflammatory bowel disease (IBD). However, identified common variants account for only a fraction of IBD heritability and largely have been identified in populations of European ancestry. We performed a genome-wide association study of susceptibility loci in Korean individuals, comprising a total of 1505 IBD patients and 4041 controls. We identified 2 new susceptibility loci for IBD at genome-wide significance: rs3766920 near PYGO2-SHC1 at 1q21 and rs16953946 in CDYL2 at 16q23. In addition, we confirmed associations, in Koreans, with 28 established IBD loci (P < 2.16 × 10<sup>-4</sup>). Our findings support the complementary value of genetic studies in different populations.
Medical subject headings
- Asian People
- Chromosomes, Human, Pair 1
- Chromosomes, Human, Pair 16
- Colitis, Ulcerative
- Crohn Disease
- Genetic Predisposition to Disease