MetaMass, a tool for meta-analysis of subcellular proteomics data.
Where this comes from
- Record sourced from PubMed, PMID 27571551.
- Also identified by DOI 10.1038/nmeth.3967.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
We report a tool for the analysis of subcellular proteomics data, called MetaMass, based on the use of standardized lists of subcellular markers. We analyzed data from 11 studies using MetaMass, mapping the subcellular location of 5,970 proteins. Our analysis revealed large variations in the performance of subcellular fractionation protocols as well as systematic biases in protein annotation databases. The Excel and R versions of MetaMass should enhance transparency and reproducibility in subcellular proteomics.
Medical subject headings
- Meta-Analysis as Topic
- Proteins
- Proteomics
- Subcellular Fractions