Viral Genome Sequencing Proves Nosocomial Transmission of Fatal Varicella.

Depledge, Daniel P; Brown, Julianne; Macanovic, Jasna; Underhill, Gill; Breuer, Judith · J Infect Dis · 2016

case_report · Level V

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Abstract

We report the first use of whole viral genome sequencing to identify nosocomial transmission of varicella-zoster virus with fatal outcome. The index case patient, nursed in source isolation, developed disseminated zoster with rash present for 1 day before being transferred to the intensive care unit (ICU). Two patients who had received renal transplants while inpatients in an adjacent ward developed chickenpox and 1 died; neither patient had direct contact with the index patient.

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