Dual-Stage Crosslinking of a Gel-Phase Bioink Improves Cell Viability and Homogeneity for 3D Bioprinting.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27581767.
- Also identified by DOI 10.1002/adhm.201600636.
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Abstract
Current bioinks for cell-based 3D bioprinting are not suitable for technology scale-up due to the challenges of cell sedimentation, cell membrane damage, and cell dehydration. A novel bioink hydrogel is presented with dual-stage crosslinking specifically designed to overcome these three major hurdles. This bioink enables the direct patterning of highly viable, multicell type constructs with long-term spatial fidelity.
Medical subject headings
- Bioprinting
- Cell Survival
- Hydrogel, Polyethylene Glycol Dimethacrylate
- Tissue Engineering