Modeling Type 2 Diabetes GWAS Candidate Gene Function in hESCs.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 27588741.
- Also identified by DOI 10.1016/j.stem.2016.08.010.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Type 2 diabetes is a complex polygenic disorder that affects about 1 in 12 adults. In this issue of Cell Stem Cell, Zeng et al. (2016) elegantly combine CRISPR-based gene editing in hESCs with directed β cell differentiation to investigate the functions of genes highlighted by genome-wide association studies (GWAS) for this disease.
Medical subject headings
- Diabetes Mellitus, Type 2
- Genome-Wide Association Study